I’m perplexed, if given systemically, does it just regrow missing teeth or try to a grow a 3rd tooth where there’s already a functioning adult tooth in place?
Apparently, it really is a thing: https://techfixated.com/human-trials-begin-for-drug-that-could-let-adults-regrow-teeth-for-the-first-time/
Interesting, but the article also feels llm-generated.
Definitely LLM… the “author” has 1624 posts since December 10, 2024. And all of the early ones are those stupid SEO-optimized “how to fix x” posts. (including one that’s literally about how to fix X/twitter lol).
Pretty sure the photo would be. Teeth grow inside the gums…
Some pictures are meant to be demonstrative and intentionally inaccurate for said demonstration.
My assumption was that’s what they were going for.
speaking around a robot’s metal cock voice
Makes sense, looks super strange haha
Nginx forbidden
Sweet. I lost a few molars in sports accidents and gincidents, so I’d love this. Maybe not the tiny Deadpool arm style of tooth part.
Was gincidents a typo, or were they gin-related incidents?
The latter. My wife coined it when she broke her wrist when stumbling after a few gins.
From what I can see, it effectively simulates the same thing that happens as a child, aka you lose you existing teeth for the new set, which means there’s always the risk they won’t come in properly, in the right angle… Sounds like a massive headache to replace a tooth of two.
Big Dentistry will be hiring Agent 47 soon from the looks
Nah the dentists like it but the denture people don’t
I’ve read about this thing a few times over the last years. It seems all research is done in Japan, there’s a lot of fuss about it, but as far as I know it has never been proven to work if the tooth to be replaced is a permanent tooth. There is a lot of hype from the scientists “wo do believe it will work” kind of stuff.
See my other comment itt for the source.
The animal data that convinced regulators and researchers to proceed to human trials represents years of painstaking experimental work.
In the mouse studies published in scientific journals since 2018, blocking USAG-1 consistently produced supernumerary teeth in animals that should have grown only their standard set.
The ferret studies were particularly significant, because ferrets, like humans, are diphyodont, meaning they naturally develop only two sets of teeth in a lifetime.
When ferrets were treated with the USAG-1 blocking antibody, they grew additional teeth beyond their natural adult set.
The teeth were complete.
They were functional.
They bonded with the surrounding bone and tissue in the same way naturally occurring teeth do.
Great article that source, and it seems to agree with me ( I know…)
There is a version of this story circulating in popular media that frames it simply as a drug that grows back the teeth you lost as an adult. That framing is exciting but premature, and it is worth being precise about what the current trial is and is not. The Phase I trial is a safety study, not an efficacy trial. Its participants are healthy adult men missing at least one molar. The trial’s primary purpose is to determine whether the drug causes any adverse effects at human doses, not yet to demonstrate that a new tooth has grown in its place. The timeline for broader clinical use reflects this reality. The development timeline includes Phase I safety trials through 2025, Phase II efficacy trials in children with congenital tooth loss through 2027, and Phase III large-scale trials through 2029. Researchers aim for general availability by 2030. And even when the drug eventually reaches the market, the initial patient population will be children born without teeth due to genetic conditions, not adults who need a molar replaced.
Not sure why they need a phase3 at all. That’s an efficacy trial, efficacy should be obvious at phase 2 and the could get approval.
They should trial through the Australian TGA, it would take years off the time.
Isn’t that how most clinical trials work though? The post doesn’t imply that it’s solved or widely available yet
(aside from the chipped tooth photo in the thumbnail I guess)
The headlines suggest tooth regrow will be available in a few years. And it might, if you’re an infant who’s missing a tooth under specific circumstances. Also, in this case the scientist is hinting at more than he can deliver right now (based on the research), and he conveniently has co-founded a company to develop this drug. Let’s just say I hope to be proven wrong, I could use three new teeth since I lost the previous ones 35 years ago.
Does that mean we can now get multiple rows like a shark?
I had a friend that said they had those, I never saw it though. I bet there are people who do, or they were fucking with me.
I had a couple of extras. Most were no big deal, but I had to have one extracted because it was blocking my adult tooth from coming in.
Nah, my sister had real messed up teeth when she was young, and the dentist referred to it as “shark mouth”. It wasn’t multiple rows, but several of her teeth had an extra tooth right behind it, leading to her mouth being pretty cluttered until they extracted the extras. Not nearly as extreme as an actual shark, but still a lotta teeth if you were able to see 'em
You kid, but the reason we can regrow teeth like this is that we actually have the cells for a third row of teeth. Once these ones are gone, though, you don’t have any more back-ups.
See, that’s the sort of forward-thinking that I want from everyone.
What if something goes wrong and you just keep growing teeth? And you just have too many teeth. Then the teeth start growing in places where they shouldn’t.
Vagina Dentata might become a real thing after all.
Everyone needs to read the article. We all have the ability to grow a third set of teeth. This drug takes away what’s suppressing that third set. I’m not saying it’s safe, but what you’re worried about isn’t the issue.
the issue is whether the new teeth will have proper enamel , or be soft and decay prone like wisdom teeth.
Wait, is that a thing? I have all my wisdom teeth and I think most of them have fillings and awful dentin visible.
Some people’s wisdom teeth have weak enamel, some are like normal teeth.
Tooth armour! Try punching me now, Ryan from year 8!
Finally. I’m very much looking forward to this
Same. I’m down to have all my teeth removed and let new ones grow in, to repair the gum-line corrosion from my early childhood that leaves me highly susceptible to cavities. I have more fillings than teeth at this point.
I would rather do a hollywood smile for all my teeth, just replace all that weak, natural mineral.
Replace it with glorious artificial matter! The flesh is weak, And so are it’s products!
Phyrexian?
Praise the Omnissiah
Me too! My wisdom teeth grew in sideways and fucked up all my teeth even cracking a few.
I was lucky enough that my wisdoms were pretty much full size by 17, and demanded all 4 get removed before they could cause issues with other teeth/my gums - tops grew in impacted (fully grown, but 90% below the gum line), bottoms were sideways and gearing up to wreck my other teeth if they stayed.
I got mine removed even though only one was coming in partially sideways, and I had an extra one, a little baby fifth wisdom tooth. It’s not all that uncommon I guess.
I simply chose to not have wisdom teeth.
I kept all of mine; more teeth for me.
I tagged you 😇
One more step towards humans becoming sharks, let’s go for cancer resistance next
Humans can become crab. Or how we say it in german: Menschen können Krebs bekommen.
it’s a myth sharks don’t get cancer.
Whales get cancer, then their cancer gets cancer, and dies from cancer. Literally too big to fail.
I demand a citation
I can do you one better: https://www.youtube.com/watch?v=1AElONvi9WQ
Would be interested to know about this. As to the previous commenter, I saw stuff about greenlandic sharks that live to be like 600 years old or more, but they are covered with like parasite growths and stuff. But the cold is a preservative things live longer in the cold if they don’t freeze.
So that’s why US-Americans are so fat, they really are smarter than the rest of us, like they have always been saying. They are trying to mimic whales so that they can make sure they never get cancer and don’t have to pay a billion in medical costs. Truly 3D-chess they are playing.
I didnt say that, I said “resistance”
I always giggle when I see this treatment mentioned because the gene they block (I think that’s how they explained it) is usag-1. Usagi in Japanese is rabbit, an animal known for their ever-growing teeth.
No fucking chance. I don’t want teeth growing in my asshole or somewhere. You guys can be the guinea pigs first.
You sure? Kinda solves the whole corn problem.
The corn problem is already solved by chewing the corn with the teeth you have - in your mouth.
Yeeah, honestly this sounds like the premise of a peculiar body-horror game.(pls mention me if it ever really happens)
Oh come now, you will only have teeth growing out of your asshole if you have a certain type of tumor on your asshole, that does sometimes grow teeth and I think hair, it’s weird.
How can I join this testing?
Little known fact. Hockey players start out able to read. The longer they play the sport their abilities just degrade.
When hair?..
From searching around, it seems some people had luck regrowing hair with… um… estrogen.
I wonder which grows first, the hair or the boobs.
Boobs
Really, do you have a link for that, or I can look for myself I guess. There is a link between male pattern baldness and androgen which is a male hormone, all the hormones are interconnected with each other on feedback loops, so it’s not entirely out of reason to think estrogen could prevent it or whatever.
That said, baldness is hereditary, and it is passed from your mother’s father, as I was taught in school, and it has checked out everywhere I have looked into it.
I myself have reversed some male pattern baldness, so I know it’s anecdotal, but it can be reversed somewhat. It’s mostly because my testosterone is suppressed by Spironolactone which is an anti-androgen rather than because I have estrogen in my body though.
Finasteride targets that specific hormone though without affecting the rest of your testosterone as much though. If I were to recommend anything to you, finasteride is probably the way to go unless you want to be a girl, in which case I will never stop you. Hims is a good place to go for Finasteride
Estrogen does have milder antiandrogenic effects though. Some trans people can go on only estrogen and keep the testosterone away
I haven’t found anything official (research).
It might even be some different drugs, I don’t know what everything is part of HRT, but I’ve seen quite a few pictures of MtF people regrowing hair after like 1-2 years.It’s DHT. Estrogen does prevent male pattern baldness and slightly reverses it, it’s a known thing for trans women. If you don’t think having your own pair of tits sounds rad as hell though you could just take finestride which is a dht blocker. Fair warning idk if dht does anything most men want, consult your doctor or at least search side effects if you’re more the “buy hormone blockers off the internet” type
Don’t forget if your in America the loss of rights, the hate, and possible threat of physical violence if you have your own pair of tits.
America hates tit havers for some stupid reason. Very odd.
You want hair in your mouth? /s
Hahaha #eitm
