I’m in this picture and I don’t like it.

Python

def process(input, part2=False):
    if part2:
        input = re.sub(r'don\'t\(\).+?do\(\)', '', input) # remove everything between don't() and do()
    total = [ int(i[0]) * int(i[1]) for i in re.findall(r'mul\((\d+),(\d+)\)', input) ]
    return sum(total)

Given the structure of the input file, we just have to ignore everything between don’t() and do(), so remove those from the instructions before processing.