I typically prefer subbed; watching dubbed feels off somehow. Then again, I’m perfectly fine with the dubbing in DBZA so it must be a preference I learned somewhere!

Particles of light

Only half-right.

Ahhhh fair play. I have a lot of freedom since I’m paying out of pocket for my own use. I have a pretty beefy rig for running local, but it’s not beefy enough to run deepseek pro and the like 😬 so, I have a bunch of subscriptions to try out a bunch of different models and see what works best in my workflow. I also have a problem with making alts in games, which seems like it rhymes 🤔

Been pretty impressed with glm5.1 too, before deepseek-v4 came out, but you’d be amazed what even a smaller older coding model can do with the right config and a little proactive context management. I really hope this trend of smaller, better models for local agentic use continues.

I’ve been using deepseek v4 flash on opencode’s infra for a couple of weeks and it’s pretty solid for something so low-cost. Honestly satisfied with it over Claude, for the premium Anthropic charges. Have you tried it at all?

Until we get to the total plan limits. They don’t cover costs to infinity, you know. And for something like cancer treatment, most plans don’t actually offer enough coverage to sustain it for years, so you’re still on the hook for tens or hundreds of thousands of dollars after all is said and done.

No, that guy holding a swastika flag at a Nazi march isn’t a Nazi. You don’t know anything else about him!

I don’t need to, though - and now, I don’t need to know anything else about the guy who said that, either.

I hate how transparent and low-effort your trolling is. Yes, there are Nazis in Ukraine. They’re not in power, and it still doesn’t justify Russia’s unprovoked war of aggression.

Now, before you spout off about literally anything else to avoid addressing that point: don’t bother. Instead, try harder. We’ll still see you for what you are, but at least it might be more of a challenge and you might experience some character growth along the way.

In real chemistry, a substance that improves a reaction somehow (speeds it up, slows it down, makes it happen in the first place) but is not consumed in the reaction is called a catalyst. It’s not a cheat.

But, Minecraft is a game. The fun is, at its core, learning. Does building a powder-duping machine make the game more or less fun for you?

Don’t be a dick.

This was exactly my read as well. It’s wild how few people can see “the other side of the coin” of what they say.

Why didn’t the person that died just not die? Are they stupid?

• A person who was not there and did nothing to help

The amyloid hypothesis has been supported by fraud for 20 years.

Pharma made drugs that dropped amyloid by 30% and they do NOTHING despite FDA approvals.

Okay, got any sources for that, or should we take you at your word?

Mouse models do not get dementia.

I don’t believe I said they did. Why the confrontational tone?

Misleading headline. What they actually demonstrated is reversing amyloid accumulation and the cognitive deficits in a transgenic mouse whose pathology is essentially just amyloid accumulation. Calling that “reversing Alzheimer’s” treats amyloid buildup and the disease as the same thing, which is exactly the conflation the amyloid hypothesis has been criticised for over the last decade.

Alzheimer’s in humans is amyloid + tau tangles + neuroinflammation + vascular dysfunction + actual neurodegeneration (entorhinal and hippocampal neurons dying, brain volume measurably dropping on MRI). Tau burden correlates with cognitive decline far better than amyloid does. The IBEC paper addresses one of those layers, the upstream-ish one, in a model that doesn’t reproduce most of the others. Fixing a cause in a young system before damage has accumulated is just not the same operation as fixing an established disease in an old human cortex that’s already lost the cells.

The human translation data backs this up. Lecanemab clears plaques and slows cognitive decline by about 27% over 18 months. Donanemab clears around 76% of plaques and slows decline by ~35% in early AD. In both trials both arms still declined, treatment just declined a bit more slowly. Northwestern’s Mesulam Institute puts it bluntly: “These medications do not reverse existing disease or stop the progression.” So removing amyloid in a system that already has the full human pathology bends the curve, it doesn’t undo anything.

What the IBEC team has here is a genuinely interesting result for the cerebrovascular angle, where BBB dysfunction and glymphatic clearance failure are upstream of plaque accumulation rather than a downstream consequence. The LRP1 transport mechanism and the multivalent ligand design are clever and well-grounded. The fair claim is “we improved amyloid clearance and rescued behavioural deficits in an amyloid-overexpressing mouse by targeting BBB transport.” That’s a real contribution. “Reversed Alzheimer’s” sells the mechanism by overstating what it did, and it sets up the same disappointment cycle the field has been through with every other anti-amyloid intervention that worked great in mice.

Original paper, for anyone wanting the actual data: https://doi.org/10.1038/s41392-025-02426-1

Yes, they really should go to prison, for really reals, if they really kill, maim, or otherwise injure another person or damage property.

If they don’t hurt or kill anyone, and don’t damage property, you might convince me their vehicle and license should be confiscated, and they should be banned from driving for life.

The only thing dumber than your comments is the Piefed decision to replace the downvote button with an emoji button that doesn’t load until just before I try to click the close button.

Sexist men tell women they have loose vaginas to try and shame them for their sex organs. Arguing it’s true is also sexist.

I only made one citation in my comment and the source was the propaganda of the DPRK itself. You may want to check again who you’re responding to because you seem confused.

Cool story. North Korea is so dystopian they put out a film called “A Day In The Life”: https://www.themoviedb.org/movie/47357-noord-korea-een-dag-uit-het-leven

And, even though this is their “best foot forward”, it makes the whole country look like what the rest of us would consider a goddamn prison camp. The stories about North Korea are insane, but they are accurate.

but I feel like what the 박연미 types are saying are either exaggerated or false, as the south and US think tanks pays them to come up with the most insane story

Only an idiot would shill for brutal dictatorships like this, ignoring all available evidence in favour of their feelings. Congratulations, you’re a Donald Trump voter.

I’m so fucking confused, man. I’m a tech guy. I’ve spent my whole life getting good with computers, I know very little about cars, and I just can’t keep up. I’ve heard that yeah ethanol is bad but put in your tank what the manual says because if your engine isn’t designed for “high-octane” fuel (???) you’ll damage your car with the pure stuff? But I know how ethanol dries out rubber, which I’m quite sure is what my fuel lines are made of, but my manual says to use 85. So should I be using 87 and avoiding 85? Or…?

I just want an electric car. “Plug it in”, I get.

Edit: Thank you to everyone who responded! It was salient as I was actually driving at the time and saw the comments before my next stop; I ended up getting the right gas thanks to you all. My car immediately started running better. I’m a lot less confused now, I’ll be using 87 gas from now on. Thankfully my car seems to have survived my mistake(s) without any immediately negative consequences >.>

Fuck yeah. Who doesn’t like good news? 🎉 Also, really surprised they got it working well enough on RDNA 2 to plan to release it, that’s just gravy on the cake.

Yeah, I know. Motherfuckers be crazy, though.