I’ll go first. Mine is the instant knockout drug. Like Dexter’s intramuscular injection that causes someone to immediately lose consciousness. Or in the movie Split where there’s the aerosol spray in your face that makes you instantly unconscious. Or pretty much any time someone uses chloroform.
Just like there were many forms of armour (plate was very expensive), there were many forms of hand weapons. And although the novels (3ven of the time) tended to romanticise the sword, it was mostly a secondary weapon, much like a handgun nowadays.