On Earth, the cardinal directions are straightforward. The arrow on a compass points to the nearest magnetic pole. You can then use it to travel anywhere on Earth.
In space, the idea of anything being “central” enough to be used as a “North” (since the universe has no center) or being fixated enough to not somehow pose issues is more convoluted.
If you were a pioneer of space exploration, what would your “North” be?
Earth, obviously. Or rather, where we think we left it…
By the time intergalactic navigation is relevant we’ll have likely dismantled Earth. The vast majority of it is just sitting there generating gravity, a huge waste of its potential.